Isolation of utero-evacuant substances from plant extracts
AssigneeOrtho Pharmaceutical Corporation
InventorRamesh M. Kanojia
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Abstract
A method of obtaining utero-evacuant substances from the zoapatle plant is described. The method involves the isolation and purification of biologically active compounds from the zoapatle plant by selective derivatization of purified material obtained from the plant.
Claims16
The method of purifying extracts containing utero-evacuant materials obtained from the zoapatle plant which comprises the steps of:
- reacting the semi-purified utero-evacuant materials with a peracid to epoxidize the .beta.,.gamma.-unsaturated system, chromatographing the reaction mixture over an adsorbent material, eluting the adsorbent material with a mixture of polar and non-polar organic solvents and collecting the fractions containing the epoxidized and unreacted utero-evacuant materials.
The method of purifying extracts containing utero-evacuant materials obtained from the zoapatle plant which comprises the steps of:
- reacting the semi-purified utero-evacuant materials with a reagent selected from an acylating agent and etherifying agents, reacting the ester or ether formed with a peracid to epoxidize the .beta., .gamma.-unsaturated system, chromatographing the reaction mixture of polar and non-polar solvents and collecting the fractions containing the epoxidized and unepoxidized materials.
The method of purifying extracts containing utero-evacuant materials obtained from the zoapatle plant which comprises selectively reacting the semi-purified utero-evacuant materials with a peracid to epoxidize the .beta., .gamma.-unsaturated system and separating the epoxidized material from the reaction mixture.
Dependencies are inferred from the claim text.