Histidine derivatives
AssigneeReckitt & Colman Products Limited
InventorsBarry A. Morgan, Derek J. Schafer
Life of this patent
Estimating the term…
Abstract
Compounds of the formula ##STR1## wherein R, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 represent certain specified substituent groups. The compounds exhibit activity in the reserpine induced hypothermia test.
Claims14
Compounds of the formula:
- ##STR5## wherein R is hydrogen or alkyl C.sub.1-3 ;
- R.sup.1 is alkyl or alkoxy C.sub.1-3 ;
- R.sup.2 is hydrogen, alkyl or alkoxy C.sub.1-3 ;
- R.sup.3 is hydrogen, alkyl C.sub.1-6, or cycloalkyl C.sub.3-6 ;
- and R.sup.4 is hydrogen or alkyl C.sub.1-6.
Compounds of the formula:
- ##STR6## wherein R is hydrogen or alkyl C.sub.1-3 ;
- R.sup.1 is alkyl or alkoxy C.sub.1-3 ;
- R.sup.2 is hydrogen, alkyl or alkoxy C.sub.1-3.
Compounds of the formula:
- ##STR7## wherein R is hydrogen or alkyl C.sub.1-3 ;
- R.sup.1 is alkyl C.sub.1-3 ;
- R.sup.2 is hydrogen or alkyl C.sub.1-3 ;
- R.sup.3 is hydrogen, alkyl C.sub.1-6, or cycloalkyl C.sub.3-6 ;
- and R.sup.4 is hydrogen or alkyl C.sub.1-6.
Compounds of the formula:
- ##STR8## wherein R is hydrogen or alkyl C.sub.1-3 ;
- R.sup.1 is alkyl C.sub.1-3 ;
- R.sup.2 is hydrogen or alkyl C.sub.1-3.
L-Pyroglutamyl-L-histidyl-trans-3-methyl-L-prolineamide.
L-Pyroglutamyl-L-histidyl-trans-3-ethyl-dl-prolineamide.
L-Pyroglutamyl-L-histidyl-3,3-dimethyl-dl-prolineamide.
L-Pyroglutamyl-N.sup..alpha. -methyl-L-histidyl-trans-3-methyl-L-prolineamide.
L-Pyroglutamyl-L-histidyl-trans-3-methyl-L-prolinecyclohexylamide.
L-Pyroglutamyl-L-histidyl-trans-3-methyl-L-prolinehexylamide.
Dependencies are inferred from the claim text.