Method of producing pantethine
AssigneeSogo Pharmaceutical Company Limited
InventorsSaburo Uchikuga, Masataka Kuroki
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Abstract
Salt of pantothenic acid and salt of cystamine or cysteamine are caused to react under the presence of an accelerator selected from the group consisting of carbodiimides and N-hydroxy compounds without any pretreatment thereby producing pantethine or pantetheine, and the pantetheine is oxidized to produce pantethine which is a precursor of co-enzyme A.
Claims12
A method of producing pantethine comprising reacting a salt of pantothenic acid and a salt of cystamine in the presence of a carbodiimide and an N-hydroxy compound selected from the group consisting of 1-hydroxybenzotriazole and N-hydroxysuccinimide.
A method of producing pantethene comprising reacting a salt of pantothenic acid and a salt of cysteamine in the presence of carbodiimide and an N-hydroxy compound selected from the group consisting of 1-hydroxybenzotriazole and N-hydroxysuccinimide to product pantethenine, and oxidizing said pantethenine to product pantethene.
A method of producing pantethine comprising causing a salt of pantothenic acid selected from the group consisting of calcium salt sodium salt and ammonium salt to react with a salt selected from the group consisting of hydrochloride and sulfate of cystamine or of cysteamine in the presence of dicyclohexylcarbodiimide and a N-hydroxy compound selected from the group consisting of 1-hydroxybenzotriazole and N-hydroxysuccinimide.
Dependencies are inferred from the claim text.