Aroyl-substituted phenylmalonic acid derivatives
AssigneeJanssen Pharmaceutica NV
InventorsPaul Adriaan Jan Janssen, Georges Henri Paul Van Daele, Jozef Martin Boey
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Abstract
Compounds of the class of aroyl-substituted phenylacetic acids and corresponding esters, amides and hydroxamic acids, useful as anti-inflammatory agents and certain novel precursors therefor.
Claims9
A diloweralkyl malonate having the formula:
- ##STR32## wherein:
- ArCO is an aroyl substituent the Ar function of which is a member selected from the group consisting of 2-thienyl, 5-methyl-2-thienyl, 5-chloro-2-thienyl, 2-naphthyl and 3-pyridyl;
- R is a member selected from the group consisting of hydrogen, loweralkyl and halo, provided that when said R is halo, then said Ar is 2-thienyl-5-methyl-2-thienyl or 5-chloro2-thienyl;
- R.sub.2 is a member selected from the group consisting of hydrogen, allyl and loweralkyl.
Diethyl 2-methyl-2-[p-(2-thenoyl)phenyl]malonate.
Diethyl 2-[3-chloro-4-(2-thenoyl)phenyl]-2-methylmalonate.
Diethyl 2-methyl-2-[p-(3-pyridylcarbonyl)phenyl]-malonate.
Diethyl 2-methyl-2-[p-(5-methyl-2-thenoyl)phenyl]-malonate.
Diethyl 2-methyl-2-[p-(2-naphthoyl)phenyl]malonate.
Diethyl 2-ethyl-2-[p-(2thenoyl)phenyl]malonate.
Diethyl 2-allyl-2-[p-(2-thenoyl)phenyl]malonate.
Diethyl 2-methyl-2-[p-(2-thenoyl)-m-tolyl]malonate.
Dependencies are inferred from the claim text.