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AssigneeFuji Chemical Industries Co., Ltd.
InventorsHiromasa Nakamoto, Shin-Ichi Nakamoto, Hidemitu Amemiya, Souji Miyamura, Motoo Shiba, Nobuko Nakamura
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Novel compound of the following formula ##STR1## wherein X is a member selected from the group consisting of carboxy and carbalkoxy and each or R.sub.1, R.sub.2 and R.sub.3 is a member selected from the group consisting of hydrogen, alkyl, alkenyl, aryl, alkoxy, hydroxy, halo, amino, alkylamino, alkylmercapto, nitro, cyano, alkylsulfonyl, carboxy, carbalkoxy, hydroxyalkyl, aminoalkyl, hydroxyalkylamino, and acetoxyalkylamino, and pharmaceutically acceptable acid addition salts thereof. The above compound can be prepared by heating a 3-(substituted amino)-acridine to cyclize said compound, and if desired, hydrolyzing the resulting product and/or it with an acid.
A member selected from the group consisting of a compound of the formula ##STR22## wherein X is a member selected from carboxy and C.sub.1 - C.sub.6 alkoxy-containing carbalkoxy, and each of R.sub.1, R.sub.2 and R.sub.3 is a member selected from the group consisting of (1) hydrogen, (2) C.sub.1 - C.sub.10 alkyl, (3) C.sub.2 - C.sub.6 alkyl-containing alkenyl, (4) C.sub.6 - C.sub.10 aryl which is unsubstituted or substituted by a member of a group consisting of C.sub.1 - C.sub.5 alkyl, halogen, nitro, C.sub.1 - C.sub.5 alkylamino, hydroxy and C.sub.1 - C.sub.5 alkoxy, (5) C.sub.1 - C.sub.4 alkyl-containing alkylamino, (6) C.sub.1 - C.sub.6 alkyl-containing alkylmercapto, (7) nitro, (8) cyano, (9) C.sub.1 - C.sub.2 alkyl-containing alkylsulfonyl, (10) carboxy, (11) C.sub.1 - C.sub.6 alkoxy-containing carbalkoxy, (12) C.sub.1 - C.sub.6 alkyl-containing hydroxyalkyl, (13) C.sub.1 - C.sub.3 alkyl-containing aminoalkyl, (14) C.sub.1 - C.sub.2 hydroxyalkylamino, and (15) C.sub.1 - C.sub.2 alkyl-containing acetoxyalkylamino and a pharmaceutically acceptable acid addition salt thereof.
Dependencies are inferred from the claim text.