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US 4,060,526 AGranted
1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof
AssigneePennwalt Corporation
InventorBola Vithal Shetty
Life of this patent
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Abstract
1-heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones, acid addition salts thereof, and intermediate compounds having analgesic properties. A representative quinazolinone compound is 1-[2-(1-phenyl-4-piperazinyl)-ethyl]-2-phenyl-1,2,3,4-tetrahydro-4-quinazo linone. A representative analgesic intermediate is 2-[2-(4-[1-phenyl]piperazinyl)ethylamino]benzamide.
Claims6
A member of the group consisting of (a) a compound having the formula:
- ##STR8## wherein:
- R is H, alkyl of 1-4 carbons, hydroxy, alkoxy of 1-4 carbons, halogen, amino, --NHCOCH.sub.3 or --NHCHO;
- A is (CH.sub.2).sub.n, where n is 1-5, or branched chain alkyl of 3-5 carbons;
- R.sub.1 is alkyl of 1-4 carbons;
- phenyl;
- phenyl substituted with NH.sub.2, OH, OCH.sub.3 or Cl;
- H when R is other than H or halogen;
- or phenalkyl of 7-10 carbons;
- R.sub.2 is H or alkyl of 1-4 carbons;
- R.sub.6 is H;
- alkyl of 1-4 carbons;
- alkanoyl of 1-4 carbons;
- benzoyl;
- phenyl;
- phenalkyl;
- or phenyl or phenalkyl substituted in the ring with NH.sub.2, OH, OCH.sub.3 or Cl;
- R.sub.7 is piperidyl, pyrrolidyl, --NH.sub.2, --NH-alkyl of 1-4 carbons, or --N.dbd. (disubstituted with alkyl of 1-4 carbons);
- and
- (b) a pharmacologically acceptable acid addition salt thereof.
16 more elements
Dependencies are inferred from the claim text.