Tobacco and tobacco-containing manufactures containing an ingredient having physiological cooling activity

A tobacco or tobacco-containing manufacture comprising tobacco and an agent capable of stimulating the cold receptors of the nervous system of the nasal or oral mucosa when brought into contact therewith upon use of the manufacture, wherein said agent comprises an effective amount of a cold receptor stimulating N-substituted p-methane carboxamide of the formula:

• ##STR2## Where R', when taken separately, is hydrogen or an aliphatic radical containing up to 25 carbon atoms and selected from alkyl, cycloalkyl, cycloalkylalkyl, hydroxyalkyl, alkynyl, hydroxyalkynyl, acyloxyalkyl, alkoxyalkyl, aminoalkyl, acylaminoalkyl, calboxyalkyl and alkylcarbonyalkyl;
• R", when taking separately, is hydroxy, or an aliphatic radical containing up to 25 carbon atoms and selected from alkyl, cycloalkyl, cycloalkylalkyl, hydroxyalkyl, alkynyl, hydroxyalkynyl, acyloxyalkyl, alkylcarbonyalkyl, with the proviso that when R' is hydrogen R" may also be an aryl radical of up to 10 carbon atoms and selected from the group consisting of benzyl, pyridyl, and substituted phenyl wherein the substituents are selected from C.sub.1 - C.sub.4 alkyl, hydroxy, C.sub.1 - C.sub.4 alkoxy, nitro and halogen;
• and
• R' and R", when taken together with the nitrogen atom to which they are attached, represent a cyclic or heterocyclic group of up to 25 carbon atoms.