Multilayer membrane useful as synthetic skin
AssigneeMassachusetts Institute of Technology
InventorsIoannis V. Yannas, John F. Burke, Philip L. Gordon, Chor Huang
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Abstract
A multilayer membrane, which is useful as synthetic skin, is disclosed herein. A first layer is formed from a material which does not provoke an immune response and which is also insoluble and nondegradable in the presence of body fluids and/or body enzymes. Preferred materials for the first layer are crosslinked composites of collagen and a mucopolysaccharide. A second layer is formed from a nontoxic material which controls the moisture flux of the overall membrane to about 0.1 to 1 mg./cm.sup.2 /hr. Suitable materials for the second layer include synthetic polymers such as silicone resins, polyacrylate or polymethacrylate esters or their copolymers, and polyurethanes.
Claims24
A multilayer membrane, comprising:
- a. a first layer formed from a crosslinked collagen-mucopolysaccharide composite containing at least about 0.5% by weight mucopolysaccharide;
- and,
- b. a moisture transmission control layer formed from a nontoxic material, said moisture transmission control layer providing said multilayer membrane with a moisture flux of from about 0.1 to about 1 mg/cm.sup.2 /hr.
A multilayer membrane of clam 3 wherein said collagen-mucopolysaccharide composite contains a sulfate-containing mucopolysaccharide.
Synthetic skin comprising a first layer formed from a crosslinked collagen-mucopolysaccharide composite bonded to a nontoxic moisture transmission control layer which provides said synthetic skin with a moisture flux of from about 0.1 to about 1 mg/cm.sup.2 /hr.
Synthetic skin of clam 20 having an overall thickness of from about 25 to about 100 mils.
Synthetic skin comprising a multilayer membrane having a first layer formed from a crosslinked collagen-mucopolysaccharide composite and a moisture control layer which provides the multilayer membrane with a moisture flux substantially equal to normal skin.
A multilayer membrane, useful as synthetic skin, comprising:
- a. a first layer formed from a crosslinked collagen-mucopolysaccharide composite material which:
- (1) has controllable degradability in the presence of body enzymes;
- (2) has controllable solubility in the presence of body fluids;
- (3) is substantially nonimmunogenic upon grafting or implantation;
- and, (4) provokes no substantial foreign body response upon grafting or implantation;
- and,
- b. a moisture transmission control layer which provides the multilayer membrane with a moisture flux substantially equal to normal skin.
Dependencies are inferred from the claim text.