Derivatives of substituted n-alkyl imidazoles
AssigneeSyntex (U.S.A.) Inc.
InventorKeith A. M. Walker
Life of this patent
Estimating the term…
Abstract
Compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 are each independently alkyl, cyclohexyl substituted with from one to three lower alkyl groups, or a group of the formula ##STR2## WHEREIN M IS AN INTEGER OF FROM 0 TO 3 AND P IS AN INTEGER OF FROM 1 TO 3; X is sulfur or oxygen; n is an integer of from 1 to 8; and the antimicrobial acid addition salts thereof are useful as antifungal, antibacterial and antiprotozoal agents.
Claims33
A compound of the formula ##STR18## wherein X is sulfur, n is 1 or 2, and R.sup.1 and R.sup.2 are each independently straight chain alkyl of from 1 to 12 carbon atoms such that the total number of carbon atoms in R.sup.1 and R.sup.2 is between 7 and 18;
- and the antimicrobial acid addition salts thereof.
A compound of the formula ##STR19## wherein X is oxygen, n is 1 or 2, and R.sup.1 and R.sup.2 are each independently straight chain alkyl of from 1 to 12 carbon atoms such that the total number of carbon atoms in R.sup.1 and R.sup.2 is between 8 and 20;
- and the antimicrobial acid addition salts thereof.
A composition useful for inhibiting the growth of fungi, bacteria or protozoa which comprises an effective amount of a compound of the formula ##STR20## wherein X is sulfur or oxygen, n is 1 or 2, and R.sup.1 and R.sup.2 are each independently straight chain alkyl of from 1 to 12 carbon atoms, such that the total number of carbon atoms in R.sup.1 and R.sup.2 is between 7 and 18 when X is sulfur and between 8 and 20 when X is oxygen;
- or an antimicrobial acid addition salt thereof;
- in an admixture with a suitable carrier.
A method of inhibiting the growth of fungi, bacteria or protozoa which comprises applying to a host object containing, or subject to attack by, fungi, bacteria or protozoa, an effective amount of a compound of the formula ##STR21## wherein R.sup.1 and R.sup.2 are each independently alkyl of from 1 to 12 carbon atoms, cyclohexyl substituted with from one to three lower alkyl groups each having from 1 to 4 carbon atoms, or a group of the formula ##STR22## wherein m is an integer of from 0 to 3 and p is an integer of from 1 to 3;
- X is sulfur or oxygen;
- n is an integer of from 1 to 8;
- or an antimicrobial acid addition salt thereof;
- or a composition containing same as an active ingredient.
Dependencies are inferred from the claim text.