Bone cement compositions containing gentamycin
AssigneeKulzer GmbH
InventorsAlbert Gross, Roland Schaefer, Siegfried Reiss
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Abstract
A bone cement composition includes, as the principal component, powdered copolymers of methyl methacrylate and methyl acrylate, or monomeric methyl methacrylate, and, in addition, gentamicin hydrochloride and/or gentamicin hydrobromide, or a mixture of gentamicin sulfate with sodium chloride, potassium chloride, sodium bromide and/or potassium bromide. The bone cement composition is used, for example, for cementing implants in place, for the anchoring of endoprostheses of the joints, in the treatment of skull defects, and for carrying out spinal fusions. The composition provides for antibiotic release in higher concentrations to prevent infections.
Claims13
A bone cement comprising the composition A or B, wherein:
- A comprises as the principal component a powdered copolymer of methyl methacrylate and methyl acrylate and 1.25 to 5 weight percent gentamycin in the form of the hydrochloride hydrobromide or 1.25 to 5 weight percent gentamycin in the form of the sulfate in admixture with 0.5 to 10 weight percent of sodium chloride, potassium chloride, sodium bromide or potassium bromide, and
- B comprises as the principal component monomeric methyl methacrylate and 2.5 to 10 weight percent gentamycin in the form of the hydrochloride hydrobromide or 2.5 to 10 weight percent of gentamycin in the form of the sulfate together with 1 to 20 weight percent of sodium chloride, potassium chloride, sodium bromide or potassium bromide.
Dependencies are inferred from the claim text.