Back to results
US 4,059,622 AGranted
Alkanolamine derivatives
AssigneeImperial Chemical Industries PLC
InventorsDavid James Le Count, Christopher John Squire
Life of this patent
Estimating the term…
Abstract
New 1-amino-3-(o-carbamoylalkoxyphenoxy)propan-2-ol derivatives, for example 1-t-butylamino-3-(o-N-methylcarbamoylmethoxyphenoxy)propan-2-ol, processes for their manufacture and pharmaceutical compositions containing them. The compounds possess .beta.-adrenergic blocking activity and are useful in the treatment of heart diseases and other conditions in man.
Drawings
Claims3
An alkanolamine derivative selected from the group consisting of compounds of the formula:
- ##STR20## wherein R.sup.1 is hydrogen or alkyl, hydroxyalkyl or alkenyl each of up to 6 carbon atoms;
- wherein R.sup.2 is hydrogen or alkyl of up to 6 carbon atoms;
- wherein R.sup.3 is hydrogen, or alkyl, hydroxyalkyl or alkoxyalkyl each of up to 10 carbon atoms, or cycloalkyl or alkenyl each of up to 6 carbon atoms, or phenylalkyl of up to 12 carbon atoms;
- wherein R.sup.4 is hydrogen, or halogen, or alkyl or alkoxy each of up to 6 carbon atoms, or hydroxy;
- wherein R.sup.5 is hydrogen or alkyl of up to 6 carbon atoms;
- and wherein A is straight-or branched-chain alkylene of up up to 4 carbon atoms;
- and the non-toxic, pharmaceutically acceptable acid-addition salts thereof.
4 more elements
Dependencies are inferred from the claim text.