Synthesis of dimethylaminoethyl methylmethacrylate
AssigneeAmerican Cyanamid Company
InventorsTerence Foster, Thomas Stephen Dawson
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Abstract
Yield of dimethylaminoethyl methacrylate from the reaction of methacrylic acid with dimethylaminoethanol is increased by carrying out the reaction under reflux conditions in presence of catalyst selected from sodium phenoxide and sodium 4-methoxyphenoxide and with incremental addition of the dimethylaminoethanol as the reaction proceeds. Yields as high as 89 percent are reported.
Claims5
In the synthesis of dimethylaminoethyl methacrylate by reaction of dimethylaminoethanol with methylmethacrylate in presence of a phenoxide catalyst under reflux conditions with removal of methanol-methylmethacrylate azeotrope by distillation as methanol is produced, the improvement wherein the sodium phenoxide catalyst is selected from sodium phenoxide and sodium 4-methoxyphenoxide and wherein the dimethylaminoethanol reactant is added continuously or regularly in small increments to the reaction mixture from the start and throughout the course of the reaction at a rate about the same as the rate at which the alcohol reactant is consumed.
Dependencies are inferred from the claim text.