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US 4,059,601 AGranted
8-Halo-11,12-secoprostaglandins
AssigneeMerck & Co., Inc.
InventorsEdward J. Cragoe, Jr., John B. Bicking
Life of this patent
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Abstract
This invention relates to 11,12-secoprostaglandins and processes for their manufacture. These compounds have prostaglandin-like biological activity and are particularly useful as renal vasodilators, for the treatment of hypertension, and for the prevention of thrombus formation.
Claims12
The compound having the following formula:
- ##STR24## wherein R is carboxy, a carboxy salt, or --COOY wherein Y is alkyl having from 1-10 carbon atoms;
- A is ethylene, trimethylene, .alpha.-methylethylene, .beta.-methylethylene, .alpha.,.alpha.-dimethylethylene, or .beta.,.beta.-dimethylethylene;
- Q is chloro or bromo;
- R.sup.1 is hydrogen or methyl;
- R.sup.2 is hydrogen or loweralkanoyl;
- R.sup.3 is hydrogen or methyl;
- R.sup.4 is 2,2,2-trifluoroethyl;
- or, when R.sup.4 is loweralkyl and R.sup.1 is methyl, R.sup.4 and R.sup.1 are joined to form a carbocyclic ring with from 6 to 9 members;
- or when R.sup.4 is loweralkyl and R.sup.1 is hydrogen, R.sup.4 can be joined to the carbon atom bearing R.sup.1 or OR.sup.2 to form a carbocyclic ring with from 5 to 8 members.
6 more elements
Dependencies are inferred from the claim text.