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US 4,059,588 AGranted
Process for preparing 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole
AssigneeICI Australia Limited
InventorsAsbjorn Baklien, Jan Kolm
Life of this patent
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Abstract
This disclosure relates to a process for the manufacture of compounds of the formula ##STR1## which comprises ring-closing a compound of the formula ##STR2## wherein the variables are as defined infra.
Claims3
A process which comprises contacting an acid addition salt of a compound of the formula:
- ##STR105## wherein Y is halogen, with an aqueous alkaline solution, heating the mixture at a temperature in the range between 40.degree. and 150.degree. C. to cause the formation of the free base of the dl 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole, as a separate phase separating the separate phase and recovering said product therefrom.
Dependencies are inferred from the claim text.