Back to results
US 4,059,584 AGranted
2-Acylamino-3-[3-(dialkylamino)propyl]imidazo[4,5-b]pyridines
AssigneePfizer Inc.
InventorSaul Bernard Kadin
Life of this patent
Estimating the term…
Abstract
1-[3-(Dialkylamino)propyl]-2-acylaminobenzimidazoles and 2-acylamino-3-[3-(dialkylamino)propyl]imidazo[4,5-b]pyridines and salts thereof with pharmaceutically acceptable acids, a novel class of compounds useful in the treatment of inflammatory conditions. Alternate methods of preparation are provided and the primary synthetic route is described in detail.
Claims5
A compound having the formula:
- ##STR29## and the pharmaceutically acceptable acid addition salts thereof wherein R is styryl, chlorostyryl, phenyl, or mono- or disubstituted phenyl wherein each substitutent is chloro, bromo, fluoro, trifluoromethyl, phenyl, alkoxy or alkyl, said alkoxy or alkyl having from 1 to 4 carbon atoms;
- R.sub.1 and R.sub.2 are each hydrogen, chloro, bromo, fluoro, trifluoromethyl, methoxy or methyl;
- X is nitrogen;
- and R.sub.3 and R.sub.4 when taken separately are each alkyl having from 1 to 4 carbon atoms and when taken together with the nitrogen to which they are attached form piperidino, pyrrolidino, morpholino, piperazino, 4-benzylpiperazino or 4-alkylpiperazino, said alkyl having from 1 to 4 carbon atoms.
1 more element
Dependencies are inferred from the claim text.