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US 4,059,576 AGranted
11-Substituted prostaglandins
AssigneeHoffmann-La Roche Inc.
InventorsGeorge William Holland, Jane Liu Jernow, Perry Rosen
Life of this patent
Estimating the term…
Abstract
11-Substituted prostaglandins E.sub.1, E.sub.2 and F.sub.2.alpha. useful as cardiovascular agents and as agents for inducing labor in pregnant females and for the termination of pregnancy and a process for preparing these prostaglandins.
Claims7
A compound of the formula:
- ##STR55## wherein R is hydrogen or lower alkyl;
- R.sub.10 is lower alkyl;
- R.sub.2 is hydroxy;
- R.sub.3 is hydrogen;
- R.sub.6 is tetrahydropyranyloxy, benzyloxy, 4-methoxy-5,6-dihydropyranyloxy, benzhydryloxy, trityloxy, trialkyl-silyloxy or methoxymethyl;
- and the dotted bond can be optionally hydrogenated;
- or its optical active enantiomers or racemates thereof.
4 more elements
A compound of the formula:
- ##STR56## wherein R and R.sub.10 are lower alkyl;
- R.sub.2 is hydroxy;
- R.sub.3 is hydrogen;
- R.sub.9 is hydrogen or lower alkyl and the dotted bond can be optionally hydrogenated;
- or its optical active enantiomers or racemates thereof.
2 more elements
A compound of the formula:
- ##STR57## wherein R is hydrogen or lower alkyl;
- R.sub.2 is hydroxy;
- R.sub.3 is hydrogen
- R.sub.6 is hydroxy, tetrahydropyranyloxy, benzyloxy, 4-methoxy-5,6-dihydro-2H-pyranyloxy, benzhydryloxy, trityloxy, trialkylsilyloxy and methoxymethyl;
- R.sub.9 is lower alkyl or fluoro;
- R.sub.9 ' is hydrogen or lower alkyl;
- R.sub.10 is lower alkyl or hydrogen;
- and the dotted carbon to carbon bond can be optionally hydrogenated
- or its optical active enantiomers or racemates thereof.
6 more elements
Dependencies are inferred from the claim text.