Extraction of N-blocked amino acids from aqueous media
AssigneeGlaxo Laboratories Limited
InventorsColin Robinson, Derek Walker
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Abstract
N-blocked amino acids, particularly derived from natural sources such as fermentation liquors, are extractively esterified from aqueous media by treatment of the aqueous solution with a diazoalkane, e.g. diphenyldiazomethane, in the presence of a water-immiscible organic solvent. Useful applications of the process include the extractive esterification of N-blocked derivatives of cephalosporin C and desacetyl cephalosporin C from fermentation broths.
Claims14
In a process for extracting an N-blocked amino acid from a fermentation broth or other aqueous solutions wherein the improvement comprises treating a fermentation broth or other predominantly aqueous solutions containing an N-blocked amino acid with a diazoalkane in the presence of a water immiscible organic solvent to substantially simultaneously esterify said N-blocked amino acid and produce a solution of the thus formed ester in said water immiscible organic solvent.
Dependencies are inferred from the claim text.