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US 4,059,512 AGranted
Process for removing endotoxin from biological fluids
AssigneePreventive Systems, Inc.
InventorNick S. Harris
Life of this patent
Estimating the term…
Abstract
A novel process for removing endotoxin from biological fluids such as parenteral fluids and for removing or reducing the level of endotoxin from the blood of animals is disclosed. The novel process includes the utilization of certain non-ionogenic hydrophobic synthetic plastic polymers that have been found to be capable of adsorbing endotoxin from the biological fluids when placed in intimate contact therewith.
Claims3
A process for selectively removing endotoxin derived from gram-negative bacilli from biological fluids, said process comprising:
- passing a biological fluid contaminated with gram-negative bacilli derived endotoxin through a microporous film, having an effective pore size of from about 0.04 to about 0.5 micrometers, of a non-ionogenic hydrophobic non-polar aliphatic synthetic plastic polymer selected from the group consisting of a substantially crystalline, non-polar aliphatic hydrocarbon thermoplastic polymer, a substantially crystalline non-polar aliphatic thermoplastic fluorocarbon polymer, a cross-linked aliphatic silicone elastomeric polymer and mixtures thereof, whereby the endotoxin is adsorbed onto the surface of the polymer;
- and
- removing the biological fluid from contact with said polymer essentially free of said endotoxin.
Dependencies are inferred from the claim text.