Tobacco and tobacco-containing manufactures containing an ingredient having physiological cooling activity

A tobacco or tobacco-containing manufacture comprising tobacco and an agent capable of stimulating the cold receptors of the nervous system of the nasal or oral mucosa when brought into contact therewith upon use of the manufacture, wherein said agent comprises an effective amount of a cold receptor stimulating substituted p-menthane of the formula:

• ##STR6## where:
• R is (i) --CONH.sub.2 ;
• or ii) --COOR', where R' is hydrogen;
• an alkali or alkaline earth metal atom, or an ammonium or substituted ammonium radical;
• or a radical containing from 2 to 10 carbon atoms and selected from hydroxyaliphatic radicals having a hydroxyl substituent in a 2- or 3-position and a hydrogen atom in the 1-position;
• a ketal derivative of such a hydroxyalophatic radical with a lower ketone;
• a lower acyl derivative of such a hydroxyaliphatic radical;
• a hydroxyaryl radical having a hydroxyl substituent in a 2- or 3-position relative to the ester grouping;
• a carboxyaliphatic radical having a carboxyl group in a 1-, 2- or 3-position;
• an alkali metal, alkaline earth metal, ammonium or substituted ammonium salt of such a carboxyaliphatic radical;
• a lower alkyl ester of such a carboxyaliphatic radical;
• and a lower alkylene oxide adduct of a hydroxyaliphatic radical having a hydroxyl substituent in a 2- or 3-position and a hydrogen atom in the 1-position.