Novel 3,15-dilower alkyl PGE.sub.2 derivatives
AssigneeYamanouchi Pharmaceutical Co., Ltd.
InventorsNoriyoshi Inukai, Masuo Murakami, Hidenori Iwamoto, Isao Yanagisawa, Toshinari Tamura, Yoshio Ishii, Tetsuya Shizaoki, Kenichi Tomioka, Tokuichi Takagi
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Abstract
3,15-Dilower alkyl prostaglandin E.sub.2 derivatives and 3,15-dilower alkyl prostaglandin D.sub.2 derivatives are disclosed. These compounds have antigastric ulcer activity without undesirable side effects to intestinal organs.
Claims8
3,15-dilower alkyl prostadienoic acid derivatives represented by the formula ##STR7## wherein B represents ##STR8## and A represents ##STR9## and R.sup.3 represents a hydrogen atom or a protective group selected from the group consisting of a tetrahydropyran-2-yl group, a trilower alkyl silyl group, a triphenylsilyl group, an acetyl group, a propionyl group, and a p-phenylbenzoyl group, R.sup.1 represents a hydrogen atom or a lower alkyl group, R.sup.2 represents a lower alkyl group, and one of R.sup.4 and R.sup.5 represents a free hydroxyl group or a hydroxyl group protected by a protective group as defined with reference to R.sup.3 and the other represents a lower alkyl group.
Dependencies are inferred from the claim text.