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US 4,058,664 AGranted
Prostaglandin C.sub.3
AssigneeThe University Court of the University of Edinburgh
InventorRobert L. Jones
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AssigneeThe University Court of the University of Edinburgh
InventorRobert L. Jones
Estimating the term…
This invention is a group of prostaglandin-like compounds of the formula: ##STR1## wherein m is 0, 1, 2, or 3 and n is 2, 3, 4, or 5, wherein X and Y are --CH.sub.2 CH.sub.2 -- or X is cis-CH.dbd.CH-- and Y is --CH.sub.2 CH.sub.2 -- or cis--CH.dbd.CH--, and wherein R.sub.1 is hydrogen, alkyl of 1 to 12 carbon atoms, inclusive, cycloalkyl of 3 to 10 carbon atoms, inclusive, aralkyl of 7 to 12 carbon atoms, inclusive, phenyl, or phenyl substituted with 1, 2, or 3 chloro or alkyl of 1 to 4 carbon atoms, inclusive, and the pharmacologically acceptable salts thereof when R.sub.1 is hydrogen. These compounds are useful as vasodepressors and antisecretory agents, and in managing cases of renal disfunction.
An optically active compound of the formula:
An optically active compound of the formula:
Dependencies are inferred from the claim text.
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From the US filing history. Foreign family members aren’t listed.
No references of this kind are recorded.
Compounds containing a five-membered ring having two side-chains in ortho position to
Acyclic or carbocyclic compounds
Term ended 15 Nov 1994 (estimated)
USPTO file history isn’t available for this patent, so only indexed dates are shown.
This invention relates to novel compositions of matter and to novel processes for making those. More specifically, this invention is concerned with novel optically active organic compounds of the formula: ##STR2## wherein m is 0, 1, 2, or 3 and n is 2, 3, 4, or 5, wherein X and Y are --CH.sub.2 CH.sub.2 -- or X is cis--CH.dbd.CH-- and Y is --CH.sub.2 CH.sub.2 -- or cis--CH.dbd.CH--, and wherein R.sub.1 is hydrogen, alkyl of 1 to 12 carbon atoms, inclusive, cycloalkyl of 3 to 10 carbon atoms, inclusive, aralkyl of 7 to 12 carbon atoms, inclusive, phenyl, or phenyl substituted with 1, 2, or 3 chloro or alkyl of one to 4 carbon atoms, inclusive, and the pharmacologically acceptable salts thereof when R.sub.1 is hydrogen.
Included within the scope of formula I wherein m is 1 and n is 3 are optically active compounds of the formulas: ##STR3## In formulas II, III and IV, R.sub.1 is as defined above.
This invention also relates to novel optically active compounds of the formula: ##STR4## wherein Z is --CH.sub.2 CH.sub.2 -- or cis--CH.dbd.CH--, and wherein R.sub.1 is as defined above, and pharmacologically acceptable salts thereof when R.sub.1 is hydrogen.