Prostaglandin-containing lyophilized powders
AssigneeSchering Corporation
InventorsRolf-Rudiger Hoffmann, Peter Fuchs
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Abstract
Lyophilized prostaglandin-containing powders are stabilized with tris(hydroxymethyl)-aminomethane hydrochloride.
Claims19
A storage-stable lyophilized prostaglandin composition comprising a prostaglandin compound and a decomposition-inhibiting quantity of tris (hydroxymethyl) aminomethane acid addition salts, said composition prior to being lyophilized having a pH of about 5-7, and the acid of said acid addition salts being other than said prostaglandin compound.
An aqueous solution of a prostaglandin compound and a decomposition-inhibiting quantity of an acid addition salt of tris(hydroxymethyl)aminomethane, said solution having a pH of about 5-7, the acid of said acid salt being other than said prostaglandin.
Dependencies are inferred from the claim text.