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US 4,058,609 AGranted
7-Dithioacetamido cephalosporins
AssigneeSmithKline Corporation
InventorRobert M. DeMarinis
Life of this patent
Estimating the term…
Abstract
Novel cephalosporins having a dithioacetamido substituent at the 7-position are prepared. These compounds have antibacterial activity.
Claims10
A chemical compound of the formula:
- ##STR2## or a non-toxic pharmaceutically acceptable salt thereof in which:
- R is lower alkyl of from 1-4 carbon atoms, trichloromethyl, trifluoromethyl, cyanomethyl, or trifluoroethyl;
- R.sub.1 is hydrogen or methoxy;
- X is SHet;
- and
- Het is triazolyl, tetrazolyl, oxazolyl, oxadiazolyl, thiazolyl or thiadiazolyl unsubstituted or substituted with one or two substituents comprising lower alkyl of 1 to 4 carbons, mercapto, trifluoromethyl or (CH.sub.2).sub.n COX where n is 0 to 5 and X is OH or NH.sub.2.
3 more elements
Dependencies are inferred from the claim text.