Ethyleneimine inactivated organisms
AssigneeBayer Aktiengesellschaft
InventorsKurt Bauer, Gunther Wittman, Manfred Mussgay, Eckart Irion, Horst Geilhausen
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Abstract
Microorganisms can be rendered inactive without impairing their antigenicity or immunogenicity by treating the microorganisms with ethyleneimine. The microorganism is placed in a suspension containing ethyleneimine up to a final concentration of 0.005 to 2% V/V. The temperature of the ethyleneimine-containing suspension is maintained between 0.degree. and 45.degree. C for between a few hours and 2 days. The excess ethyleneimine is destroyed.
Claims22
A bacteria suspension to which ethyleneimine has been added such that the concentration of ethyleneimine is 0.005 to 2% V/V, the residual unused ethyleneimine thereafter being destroyed, whereby the bacteria are inactivated without impairment to their antigenicity.
A method of rendering bacteria inactive without impairing their antigenicity which comprises adding to bacteria a suspension of ethyleneimine such that the concentration of ethyleneimine in the suspension is 0.005 to 2% V/V, maintaining the temperature of the suspension between 0.degree. and 45.degree. C for between a few hours and 2 days, and destroying the residual unused ethyleneimine.
Dependencies are inferred from the claim text.