4-Aroyl-substituted phenoxy acetic acids
AssigneeAbbott Laboratories
InventorsPeter Hadley Jones, Dilbagh Singh Bariana, Anthony Kei Lun Fung, Yvonne Connolly Martin, Jaroslav Kyncl, Amrit Lall
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Abstract
This invention provides 4-aroyl substituted phenoxy acetic acids and tetrazoles of the formula ##STR1## wherein R is a phenyl ring, a substituted phenyl ring, or naphthyl; R.sub.1 is --CH.sub.2 COOH or methyl tetrazole, and X.sub.1 and X.sub.2 are each a halogen or loweralkyl, or when taken together form with the two attached carbons a phenyl ring. These compounds are useful as antihypertensive agents, diuretics and uricosuric agents.
Claims14
A compound of the formula ##STR29## wherein R is a phenyl ring, naphthyl or a substituted phenyl ring where the substituents are loweralkyl, halogen, loweralkoxy, nitro or hydroxy;
- R.sub.1 is --CH.sub.2 COOH;
- and X.sub.1 and X.sub.2 are each a halogen, or when taken together form with the two attached carbons a phenyl ring.
A compound according to claim 1, 4(4-fluorobenzoyl)-2,3-dichlorophenoxy acetic acid.
A compound according to claim 1, 4(3-chlorobenzoyl)-2,3-dichlorophenoxy acetic acid.
A compound according to claim 1, 4(3,4-dichlorobenzoyl)-2,3-dichlorophenoxy acetic acid.
Dependencies are inferred from the claim text.