Amidinoureas
AssigneeWilliam H. Rorer, Inc.
InventorsGeorge Henry Douglas, William Lyon Studt, Stuart Alan Dodson
Life of this patent
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Abstract
A new class of chemical compounds and their process of preparation is described. These compounds have valuable properties as anti-secretory, anti-spasmodic, anti-ulcerogenic and anti-diarrheal agents.
Claims33
A compound of the formula:
- ##STR11## where:
- R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 may be the same or different and are:
- hydrogen, halo, loweralkyl, haloloweralkyl, nitro, amino, acylamino, hydroxy, aralkyloxy or loweralkoxy;
- R.sub.n is nitrogen or loweralkyl;
- R.sub.7, r.sub.8, r.sub.9 and R.sub.10 may be the same or different and are:
- hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl or aralkyl;
- px is 0-1;
- the sum total of carbon atoms present in R.sub.7, R.sub.8, R.sub.9 and R.sub.10 together is less than 12;
- and
- the non-toxic acid addition salts thereof.
1-(2,6-dimethylphenyl)-3-methoxyamidinourea hydrochloride.
1-(2,6-diethylphenyl)-3-(N-methoxy-N'-methylamidino)urea hydrochloride.
1-(2,6-dimethylphenyl)-3-benzyloxyamidinourea hydrochloride.
1-(2,6-dimethylphenyl)-3-hydroxyamidinourea hydrochloride.
1-(2,6-dimethylphenyl)-3-methoxyamidinourea hydrochloride.
1-(2,6-diethylphenyl)-3-methoxyamidinourea succinate.
1-(2-bromo-6-methylphenyl)-3-methoxyamidinourea hydrochloride.
1-(2-chloro-6-methylphenyl)-3-methoxyamidinourea hydrochloride.
1-(2,6-dimethylphenyl)-3-ethoxyamidinourea hydrochloride.
1-(2-chloro-6-methyl)-3-ethoxyamidinourea hydrochloride.
1-(2,6-dimethylphenyl)-3-n-butoxyamidinourea hydrochloride.
1-(2,6-dimethylphenyl)-3-n-propoxyamidinourea hydrochloride.
1-(2,6-diethylphenyl)-3-(N-methoxy-N'-methylamidino)urea hydrochloride.
1-(2-chloro-6-methylphenyl)-3-(N-methoxy-N'-methylamidino)urea hydrochloride.
1-(4-bromo-2,6-diethylphenyl)-3-methoxyamidinourea hydrochloride.
1-(4-bromo-2-chloro-6-methylphenyl)-3-methoxyamidinourea hydrochloride.
1-(2,6-diethylphenyl)-3-ethoxyamidinourea succinate.
1-(4-bromo-2,6-dimethylphenyl)-3-methoxyamidinourea hydrochloride.
1-(2,6-diethyl-4-nitrophenyl)-3-methoxyamidinourea hydrochloride.
1-(2-chloro-6-methylphenyl)-3-n-butoxyamidinourea hydrochloride.
1-(1-naphthyl)-3-methoxyamidinourea hydrochloride.
1-(2,6-diethylphenyl)-3-n-propoxyamidinourea succinate.
1-(2,6-dibromo-4-ethylphenyl)-3-methoxyamidinourea hydrochloride.
1-(4-amino-2,6-diethylphenyl)-3-methoxyamidinourea dihydrochloride.
1-(2,6-dimethylphenyl)-3-hydroxyamidinourea hydrochloride.
1-(2,6-dimethylphenyl)-3-benzyloxyamidinourea hydrochloride.
1-(2,6-diethylphenyl)-3-n-butoxyamidinourea succinate.
1-(2-chloro-6-methylphenyl)-3-n-propoxyamidinourea hydrochloride.
Dependencies are inferred from the claim text.