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US 4,058,550 AGranted
Polysubstituted-alkyl esters of 4-alkylaminobenzoic acids
AssigneeAmerican Cyanamid Company
InventorsRobert Gordon Shepherd, Thomas Gary Miner
Life of this patent
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Abstract
Polysubstituted-alkyl esters of 4-alkylaminobenzoic acids having hypolipemic activity.
Claims9
A compound of the formula:
- ##STR4## wherein R.sub.4 is an unbranched or branched alkyl group, C.sub.n H.sub.2n+1 wherein n is 8 to 19;
- R.sub.1, R.sub.2 and R.sub.3 are selected from the group consisting of hydrogen, C.sub.1 -C.sub.3 alkyl, and C.sub.1 -C.sub.3 hydroxyalkylene;
- X and Y, which may be the same or different, are selected from the group consisting of hydrogen, hydroxy, lower alkanoyloxy, hydroxymethyl, and when taken together X and Y can comprise a carbon-carbon bond;
- wherein the 4-alkylaminobenzoyloxy moiety and X may be interchanged;
- with the proviso that when R.sub.1, R.sub.2 and R.sub.3 are all hydrogen or C.sub.1 -C.sub.3 alkyl, then X and Y may not both be hydrogen;
- and the pharmaceutically acceptable salts thereof.
3 more elements
The compound according to claim 1, 2,3-dihydroxypropyl 4-(n-hexadecylamino)benzoate.
Dependencies are inferred from the claim text.