Polycyclic amino derivatives of pyrrolidone and piperidone
AssigneeCiba-Geigy Corporation
InventorsWilfried Graf, Erich Schmid
Life of this patent
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Abstract
A series of compounds of the formula ##STR1## have been found to exhibit useful pharmacological properties, e.g. antiinflammatory and analgetic activity.
Claims5
A compound of the formula ##STR39## wherein R is aryl of the formula ##STR40## each of R.sup.9, R.sup.10, R.sup.11, R.sup.12 and R.sup.13 is a member selected from the group consisting of a hydrogen atom, a chlorine atom, a fluorine atom, a bromine atom, lower alkyl, lower alkoxy, trifluoromethyl and lower alkylthio;
- A is trimethylene and B is trimethylene.
A compound of the formula:
- ##STR41## wherein R is aryl of the formula:
- ##STR42## each of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 is a member selected from the group consisting of a hydrogen atom, lower straight chain alkyl, or phenyl;
- and
- each of R.sup.9, R.sup.10, R.sup.11, R.sup.12 and R.sup.13 is a member selected from the group consisting of a hydrogen atom, a chlorine atom, a fluorine atom, a bromine atom, lower alkyl, lower alkoxy, trifluoromethyl and lower alkylthio.
8a-phenyl-1,2,3,4,6,7,8,8a-octahydro-pyrrolo[1,2-a] pyrimidin-6-one.
8a-(p-chlorophenyl)-hexahydro-pyrrolo[1,2-a] pyrimidin -6(2H)-one.
9a-phenyl-octahydro-6H-pyrido[1,2-a]pyrimidin -6-one.
Dependencies are inferred from the claim text.