Bis(benzamido)-benzene derivatives
AssigneeChugai Seiyaku Kabushiki Kaisha
InventorsTakashi Mori, Sakae Takaku, Nobuhiro Oi, Minoru Shindo, Takeaki Hirano, Shigeyuki Kataoka, Kouji Furuno
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Abstract
Bis(benzamido)-benzene derivatives having various pharmaceutical activities such as activity for preventing and treating peptic ulcer, peripheral vasodilating action, hypotensive activity and analgesic activity and represented by the formula ##STR1## wherein X, Y, Z, R.sub.1, R.sub.2 and R.sub.3 are as defined hereinafter and a process for preparing the same are disclosed.
Claims54
A bis(benzamido)-benzene derivative represented by the formula ##STR16## wherein X is direct bond, oxygen, ##STR17## or --CONH--- wherein the CO moiety is bonded to the phenylene group, R.sub.1 is straight or branched lower alkylene, R.sub.2 and R.sub.3 are the same or different and each represents lower alkyl or they may be bonded to each other directly or through a hetero atom to form piperidino or morpholino, R.sub.4 is lower alkyl and it may be bonded to R.sub.2 R.sub.3 to form piperazino and Y and Z are same or different and each represents hydrogen, lower alkyl, hydrozy, lower alkoxy, lower alkanoyloxy or halogen, and its acid addition salt.
A bis(benzamido)-benzene derivative represented by the formula ##STR18## wherein X is oxygen or --CONH-- wherein the CO moiety is bonded to the phenylene group, Y and Z are the same or different and each represents methyl, methoxy, ethoxy, hydroxy, acetoxy, chlorine or hydrogen, R.sub.1 is ethylene, propylene or butylene, R.sub.2 and R.sub.3 are the same or different and each represents methyl or ethyl or they may be bonded to each other directly or through a hetero atom to form piperidino or morpholino, and its acid addition salt.
A bis(benzamido)-benzene derivative represented by the formula ##STR19## wherein X is oxygen or --COHN-- wherein the CO moiety is bonded to the phenylene group, Y is methyl or methoxy, R.sub.1 is ethylene or propylene, and R.sub.2 and R.sub.3 are independently methyl or ethyl, and its acid addition salt.
A bis(benzamido)-benzene derivative represented by the formula ##STR20## wherein X is oxygen or --CONH--- wherein the CO moiety is bonded to the phenylene group, and Y is methyl attached to o- or m-position of the benzene, and its acid addition salt.
Dependencies are inferred from the claim text.