Adriamycins and uses thereof
AssigneeSocieta' Farmaceutici Italia S.p.A.
InventorsFederico Arcamone, Aurelio Di Marco, Sergio Penco
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Abstract
The known antitumor antibiotic adriamycin and its .beta.-anomer, and the novel compounds, 4'-epiadriamycin (both .alpha.- and .beta.-anomers) are prepared by condensing a novel, reactive protected derivative of adriamycinone with reactive intermediates which are 1-halo-2,3,6-trideoxy-3-trifluoroacetamido-4-trifluoroacetoxy-.alpha.-L-ly xo (or arabino) hexopyranoses.
Claims7
A compound selected from the group consisting of 4'-epi-adriamycin (.alpha.-anomer), 4'-epiadriamycin (.beta.-anomer) and a mixture thereof.
A method of inhibiting the growth of a tumor selected from the group consisting of Moloney Sarcoma Virus, Sarcoma 180 Ascites, Solid Sacroma 180, gross transplantable leukemia and L.sub. 1210 leukemia which comprises administering to a host afflicted with said tumor an amount of a compound selected from the group consisting of 4'-epiadriamycin, .alpha.-anomer, 4'-epiadriamycin, .beta.-anomer and mixtures thereof sufficient to inhibit the growth of said tumor.
Dependencies are inferred from the claim text.