Synthetic peptides having growth promoting activity
AssigneeAB Kabi
InventorsHans Sievertsson, Ronny Hugo Loritz Lundin, Gertrud Elisabeth Westin Sjodahl
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Abstract
Novel synthetic peptides of the general formula ##STR1## and the corresponding reduced, linear form. The cyclic form of the peptide is produced by oxidation of the corresponding linear compound thereby providing the divalent dithio group --S--S-- joining the beta carbon of each of the cysteine moieties. In the above formula X is serine (SER) or lysine (Lys), and Y is OH or Thr-Glu-Gly-Phe. The obtained synthetic peptides, in either form, are useful in promoting growth of cells of mammalian tissues.
Claims7
Synthetic peptides of the general formula ##STR8## and the corresponding reduced, linear form where the link between the two Cys moieties in the oxidized form represents the dithio group, --S--S--;
- X = Ser or Lys;
- and Y = OH or Thr - Glu - Gly -Phe.
The linear tridecapeptide aspartyl-glutaminyl-glutamyl-seryl-cysteinyl-lysyl-glycly-arginyl-cysteiny l-threonyl-glutamyl-glycyl-phenylalanine.
The cyclic tridecapeptide:
- ##STR9##
The linear tridecapeptide:
- Asp - Gln - Glu - Lys - Cys - Lys -Gly - Arg - Cys - Thr - Glu - Gly - Phe.
The cyclic tridecapeptide:
- ##STR10##
The linear nonapeptide:
- Asp - Gln - Glu - Lys - Cys - Lys - Gly - Arg - Cys - OH.
the cyclic nonapeptide:
- ##STR11##
Dependencies are inferred from the claim text.