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US 4,058,511 AGranted
Tegretol antigens and antibodies
AssigneeSyva Company
InventorPrithipal Singh
Life of this patent
Estimating the term…
Abstract
Derivatives of dibenz[b,f]azepine drugs are provided for preparation of antigens and antibodies, the antibodies finding use in immunoassays for the dibenz[b,f]azepine drugs. Specifically, N-oxoaliphatic substituted carbamoyl dibenz[b,f]azepine compounds are provided which are conjugated with antigenic materials and injected into animals for production of antibodies specific for the azepine drug.
Claims11
A compound of the formula:
- ##STR5## wherein:
- m is 0 or 1,
- R.sup.1 is a bond or an aliphatic radical of from 1 to 8 carbon atoms having from 0 to 1 site of ethylenic unsaturation as the only unsaturation and from 0 to 1 heteroatom of atomic number 7 to 8 bonded solely to carbon with the proviso that R.sup.1 has at least 2 carbon atoms when m is 0;
- Y.sup.1 is an antigenic poly(amino acid) of at least 1,000 molecular weight;
- and
- n.sup.1 is at least 1 and not greater than the molecular weight of Y.sup.1 divided by 500, with the proviso that when m is OR.sup.1 is bonded to amino groups of said poly(amino acid) by a single covalent bond to form an alkylamino and when m is 1 the carboxy carbonyl is bonded to amino groups of said poly(amino acid) by a single covalent bond to form an amide.
3 more elements
Dependencies are inferred from the claim text.