Alkyl amino-glucopyranoside derivative and process for producing the same
AssigneeTokyo Tanabe Company Limited
InventorsGoro Kimura, Junzo Sekine
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Abstract
Certain alkyl amino-glucopyranoside are disclosed, including alkyl N-carbamyl-N'-(2-chloroethyl)-N'-nitroso-6-amino-6-deoxy-D-glucopyranoside , alkyl N-carbamyl-N'-(2-chloroethyl)-N'-nitroso-2-amino-2-deoxy-D-glucopyranoside , and alkyl di-N,N'-[N-(2-chloroethyl)-N-nitroso-carbamyl]-2,6-di-amino-2,6-di-deoxy-D -glucopyranoside. The alkyl amino-glucopryanoside exhibits marked antitumor activity while not having diabetogenic activity and bone marrow toxicity. The alkyl amino-glucopryanoside is further water soluble and free from antibacterial activity.
Claims11
An alkyl amino-glucopyranoside having the following formula:
- ##STR4## in which R.sub.1 is an N-carbamyl-N'-(2-chloroethyl)-N'-nitroso-amino group, R.sub.2 is an alkyl group having from 1 to 4 carbon atoms, and R.sub.3 is an hydroxyl group or an N-carbamyl-N'-(2-chloro-ethyl)-N'-nitroso-amino group.
An alkyl amino-gluocopyranoside having the following formula:
- ##STR5## in which R.sub.3 is an N-carbamyl-N'-(2-chloroethyl)-N'nitroso-amino group and R.sub.2 is an alkyl group having from 1 to 4 carbon atoms.
Dependencies are inferred from the claim text.