Araliphatic dihalogen compounds and process for their preparation
AssigneeMerck Patent GmbH
InventorsJoachim Gante, Hans-Adolf Kurmeier, Dieter Orth, Erich Schacht, Albrecht Wild
Life of this patent
Estimating the term…
Abstract
Compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and are F, Cl or Br; Q is --CH(CH.sub.3)-CH.sub.2 --, --C(OH) (CH.sub.3)-CH.sub.2 -- or --C(CH.sub.3) .dbd.CH--; Y is COOH, COOR.sup.3, CH.sub.2 OH or CH.sub.2 OAc; n is 0 or 1; R.sup.3 is alkyl or aryl of up to 8 carbon atoms or C.sub.6 H.sub.4 NHCOCH.sub.3 ; and Ac is acyl of 1-8 carbon atoms; And physiologically acceptable salts thereof, are anti-inflammatory agents, which can be made from compounds of the formula Z -- X, wherein Z is ##STR2## AND X can be converted to --Q-Y.
Claims20
An araliphatic dihalogen compound of the formula
- Z-Q-Y
- wherein Z is ##STR9## R.sup.1 and R.sup.2 are F, Cl or Br;
- Q is --CH(CH.sub.3)---CH.sub.2 --, --C(OH) (CH.sub.3)--CH.sub.2 -- or --C(CH.sub.3).dbd.CH--;
- Y is CH.sub.2 OH and;
- n is 0 or 1.
Dependencies are inferred from the claim text.