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AssigneeLabaz
InventorsCharles Pigerol, Pierre Eymard, Jean-Claude Vernieres, Jean-Pierre Werbenec, Madeleine Broll
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Methylamine derivatives of the formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof, wherein R.sub.1 and R.sub.3 each represent a hydrogen atom or a straight- or branched-chain alkyl, alkenyl or alkynyl radical containing from 1 to 6 carbon atoms, R.sub.2 represents a straight- or branched-chain alkyl, alkenyl or alkynyl radical containing from 2 to 7 carbon atoms with the proviso that when R.sub.2 represents an alkenyl radical of the formula CH.dbd.CH--R.sub.6 or an alkynyl radical of the formula C.tbd.C--R.sub.6, in which R.sub.6 represents a hydrogen atom or a straight- or branched-chain alkyl radical of 1 to 5 carbon atoms, R.sub.1 and R.sub.3 each represent an atom of hydrogen or an alkyl radical, R.sub.4 and R.sub.5, which are the same or different, each represent a hydrogen atom, a straight- or branched-chain alkyl, alkenyl or alkynyl radical containing from 1 to 5 carbon atoms or an .omega.-hydroxyalkyl radical containing from 2 to 5 carbon atoms or R.sub.4 and R.sub.5, when they are taken together represent an alkylene radical containing from 2 to 6 carbon atoms, an alkylidene radical containing from 1 to 5 carbon atoms or the radical --CH.sub.2 --CH.sub.2 --O--CH.sub.2 --CH.sub.2 --, R.sub.1, R.sub.2 and R.sub.3 being such that the trisubstituted methylamine radical possesses no more than 13 carbon atoms. They are useful for treating Parkinson's disease and for correcting extra-pyramidal disturbances provoked by neuroleptics.
Method for treating Parkinson's disease and correcting extra-pyramidal disturbances provoked by neuroleptics comprising the administration to a subject in need of such treatment of a dosage of from 10 to 60 mg. per 60 kg. of body weight per day of at least one methylamine derivative of the formula:
Method for treating Parkinson's disease and correcting extra-pyramidal disturbances provoked by neuroleptics comprising the administration to a subject in need of such treatment of a dosage of from 10 to 60 mg. per kg. of body weight per day of N-methyl-1,1-di-n-propyl-n-butylamine or a pharmaceutically acceptable acid addition salt thereof.
Method for treating Parkinson's disease and correcting extra-pyramidal disturbances provoked by neuroleptics comprising the administration to a subject in need of such treatment of a dosage of from 10 to 60 mg. per kg. of body weight per day of N,N-dimethyl-1,1-di-n-propyl-n-butylamine or a pharmaceutically acceptable acid addition salt thereof.
A pharmaceutical or veterinary composition for use in the treatment of Parkinson's disease and for the correction of extra-pyramidal disturbances provoked by neuroleptics, said composition being in dosage unit form containing, per unit, as an essential active ingredient from 1 to 100 mg. of a methylamine derivative of the formula. ##STR24## in which R.sub.2 represents n-propyl, isopropyl or isobutyl, R.sub.4 represents hydrogen or methyl, R.sub.5 represents methyl, ethyl, isopropyl, allyl or propargyl or a pharmaceutically acceptable acid addition salt of the said derivative, in association with a pharmaceutical carrier or excipient therefor.
A pharmaceutical or veterinary composition for use in the treatment of Parkinson's disease and for the correction of extra-pyramidal disturbances provoked by neuroleptics, said composition being in dosage unit form containing as an essential active ingredient 1 to 100 mg. of N-methyl-1,1-di-n-propyl-n-butylamine or a pharmaceutically acceptable acid addition salt thereof, in association with a pharmaceutical carrier or excipient therefor.
A pharmaceutical or veterinary composition for use in the treatment of Parkinson's disease and for the correction of extra-pyramidal disturbances provoked by neuroleptics, said composition being in dosage unit form containing as an essential active ingredient 1 to 100 mg. of N,N-dimethyl-1,1-di-n-propyl-n-butylamine or a pharmaceutically acceptable acid addition salt thereof, in association with a pharmaceutical carrier or excipient therefor.
Dependencies are inferred from the claim text.