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US 4,057,642 AGranted
Acyl cyanoguanidines
AssigneeMerck & Co., Inc.
InventorsHoward Jones, Tsung-Ying Shen
Life of this patent
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Abstract
Certain novel acyl cyanoguanidines, their preparation, pharmaceutical compositions and novel methods of treating inflammation and autoimmune diseases such as rheumatoid arthritis are disclosed.
Claims5
A compound of the formula:
- ##STR5## wherein R is C.sub.1-5 alkylthiophenyl, C.sub.1-5 alkylsulfinylphenyl or C.sub.1-5 alkylsulfonylphenyl.
A pharmaceutical composition useful for treating inflammation and rheumatoid arthritis comprising a non-toxic pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of the formula:
- ##STR6## wherein R' is C.sub.1-5 alkoxyphenyl, C.sub.1-5 alkylthiophenyl, C.sub.1-5 -alkylsulfinylphenyl or C.sub.1-5 alkylsulfonylphenyl.
A method of treating rheumatoid arthritis which comprises administering to a patient a therapeutically effective amount of a compound of the formula:
- ##STR7## wherein R' is C.sub.1-5 alkoxyphenyl, C.sub.1-5 alkylthiophenyl, C.sub.1-5 -alkylsulfinylphenyl or C.sub.1-5 alkylsulfonylphenyl.
Dependencies are inferred from the claim text.