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US 4,057,637 AGranted
5-Mercaptopyridoxine esters
AssigneeMerck & Co., Inc.
InventorsTsung-Ying Shen, Howard Jones, Dennis M. Mulvey, Conrad P. Dorn
Life of this patent
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Abstract
Mercaptoalkylpyridines and various derivatives thereof have utility in the treatment of rheumatoid arthritis. The compounds useful in the method of treatment are generally prepared from known pyridine derivatives and, principally, from pyridoxine and related compounds.
Claims6
A compound of structural formula:
- ##STR93## or pharmaceutically acceptable salt thereof, wherein m is 0 or 1;
- R is C.sub.1-5 alkyl;
- R.sub.31 groups are the same or different and are hydrogen ##STR94## where R.sub.40 is C.sub.1-5 alkyl or C.sub.2-5 alkenyl, R.sub.32 is hydrogen or ##STR95## with the proviso that if both R.sub.31 groups are hydrogen and m is 0, then R.sub.32 is not hydrogen.
Dependencies are inferred from the claim text.