Carbamates of ergolines and therapeutic compositions therewith
AssigneeSimes Societa Italiana Medicinali e Sintetici S.p.A.
InventorsGiorgio Ferrari, Jiri Jan Krepinsky
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Abstract
Ergoline carbamates are disclosed, which have proven to be effective spasmolytic and vasodilatory drugs. They are derivatives of D-6-methyl-8.beta.-(methanol)-9,10-didehydroergoline (also called lysergol). Three convenient methods for their preparation are also disclosed. The toxicity of these compounds is extremely low.
Claims21
D-6-methyl-8.beta.-(phenylcarbamoylmethyl)-9,10-didehydroergoline.
D-6-methyl-8.beta.-(morpholinocarbonyloxymethyl)-9,10-didehydroergoline.
D-6-methyl-8.beta.-(4-methyl-piperazinylcarbonyloxymethyl)-9,10-didehydr oergoline.
D-6-met hyl-8.beta.-(4-phenyl-piperazinylcarbonyloxymethyl)-9,10-didehydroergoline.
D-6-methyl-8.beta.-(veratrylaminocarbonyloxymethyl)-9,10-didehydroergoli ne
D-6-methyl-8.beta.-(phenethylaminocarbonyloxymethyl)-9,10-didehydroergolin e.
D-6-methyl-8.beta.-(2-morpholinoethylaminocarbonyloxymethyl)-9,10-didehydr oergoline.
D-6-met hyl-8.beta.-(3,4-dihydroxyphenethylaminocarbonyloxymethyl)-9,10-didehydroer goline.
D-6- methyl-8.beta.-(3,4-dimethoxyphenethylaminocarbonyloxymethyl)-9,10-didehydr oergoline.
D-6-me thyl-8.beta.-(.beta.-methylphenethylaminocarbonyloxymethyl)-9,10-didehydroe rgoline.
D-6-methyl-8.beta.-(phenylcarbamoylmethyl)-ergoline.
D-6-methyl-8.beta.-(morpholinocarbonyloxymethyl)-ergoline.
D-6-methyl-8.beta.-(4-methyl-piperazinylcarbonyloxymethyl)-ergoline.
D-6-methyl-8.beta.-(4-phenyl-piperazinylcarbonyloxymethyl)-ergoline.
D-6-methyl-8.beta.-(veratrylaminocarbonyloxymethyl)-ergoline.
D-6-methyl-8.beta.-(phenethylaminocarbonyloxymethyl)-ergoline.
D-6-methyl-8.beta.-(2-morpholinoethylaminocarbonyloxymethyl)-ergoline.
D-6-methyl-8.beta.-(3,4-dihydroxyphenethylaminocarbonyloxymethyl)-ergol ine.
D-6-methyl-8.beta.-(3,4-dimethoxyphenethylaminocarbonyloxymethyl)-ergoline.
D-6-methyl-8.beta.-(.alpha.-methylphenethylaminocarbonyloxymethyl)-ergo line.
Dependencies are inferred from the claim text.