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US 4,057,631 AGranted
7-(.alpha.-Substituted phenylacetamido)-3-(1-carboxymethylthioethyltetrazolyl-5-thiomethyl)-3-c ephem-4-carboxylic acids
AssigneeSmithKline Corporation
InventorDavid A. Berges
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Abstract
New semisynthetic cephalosporins characterized by having structures with a 1-carboxymethylthioethyltetrazolyl-5-thiomethyl group at position 3. Exemplary is the antibacterially effective 7-D-mandelamido-3-(1-carboxymethylthioethyltetrazolyl-5-thiomethyl)-3-ceph em-4-carboxylic acid disodium salt.
Claims6
A compound or its nontoxic alkali metal salts, said compound being of the structure:
- ##STR3## in which:
- X is thienyl, furyl, phenyl or phenyl monosubstituted with hydroxy, hydroxymethyl, formamido or ureido;
- and
- A is NH.sub.2, OH, COOH, SO.sub.3 H, formyloxy or, when the .alpha.-C- hydrogen is absent, methoxyimino.
1 more element
Dependencies are inferred from the claim text.