Antiarthritic compositions comprising bis-coordinated gold(1+) salts and methods of producing antiarthritic activity
AssigneeSmithKline Corporation
InventorDavid Taylor Hill
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Abstract
Pharmaceutical compositions having antiarthritic activity comprising phosphine or phosphite bis-coordinated gold(1+) salts and methods of producing antiarthritic activity by administering internally, preferably orally, said compositions.
Claims14
A pharmaceutical composition hvaing antiarthritic activity, in dosage unit form, comprising a pharmaceutical carrier and an effective, nontoxic amount of a phosphine or phosphite bis-coordinated gold(1+) salt of the formula:
- [(R.sub.3 P)(R.sub.3 'P)]Au.sup.+ X.sup.-
- in which:
- R and R' which may be the same or different are phenyl, lower alkyl or lower alkoxy;
- and
- X is halide, perchlorate, or tetrafluoroborate.
The method of producing antiarthritic activity which comprises administering internally to an animal organism in an amount to produce said activity a phosphine or phosphite bis-coordinated gold(1+) salt of the formula:
- [(R.sub.3 P)(R.sub.3 ' P)]Au.sup.+ X.sup.-
- in which:
- R and R' which may be the same or different are phenyl, lower alkyl or lower alkoxy;
- and
- X is halide, perchlorate, or tetrafluoroborate.
Dependencies are inferred from the claim text.