Acne preparation for oral administration
OwnerHelmut Anton Sticklinventor
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Abstract
An acne preparation for oral administration and a method of preparing the same in which a nutrient medium, such as, meat-peptone broth is inoculated with Corynebacterium acnes, such as, Beck, Gerrath and Vogel strains and combinations thereof, fermentation is carried out, the Corynebacterium acnes are inactivated, preferably by treatment with ultrasonics, and freeze-dried, to form an immunizing constituent. This immunizing constituent is preferably mixed with metabolic products of Corynebacterium acnes as a desensitizing constituent, preferably antigens contained in the nutrient medium in which Corynebacterium acnes are cultivated. The composition may be made in the form of tablets, capsules or liquids, such as, emulsions or syrups, and may contain conventional adjuvants, carriers and/or auxiliary agents.
Claims26
An acne composition for oral administration, comprising inactivated Corynebacterium acnes as an immunizing constituent and a pharmaceutically-acceptable carrier therefor.
The composition of claim 11, in which said Corynebacterium acnes are a combination of at least two Corynebacterium acnes strains selected from the group consisting of Beck, Gerrath and Vogel.
A process for producing an acne composition for oral administration, comprising cultivating Corynebacterium acnes in a nutrient medium under anaerobic conditions until substantial growth of said Corynebacterium acnes has occurred, recovering said Corynebacterium acnes from said nutrient medium and mixing at least a portion of the metabolic products of said Corynebacterium acnes contained in said nutrient medium with said Corynebacterium acnes.
A process for producing an acne composition for oral administration, comprising cultivating Corynebacterium acnes in a nutrient medium under anaerobic conditions until substantial growth of said Corynebacterium acnes has occurred, recovering said Corynebacterium acnes from said nutrient medium and mixing urea with said Corynebacterium acnes.
Dependencies are inferred from the claim text.