Method of preparing 2,3-dichloroanisole
AssigneeSmithKline Corporation
InventorsWilford Lee Mendelson, Robert Lee Webb
Life of this patent
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Abstract
A new process for preparing 2,3-dichloroanisole comprises reacting 1,2,3-trichlorobenzene with an alkali metal methoxide preferably in the presence of methanol.
Claims8
The method of preparing 2,3-dichloro-1-loweralkoxybenzenes comprising the reaction of 1,2,3-trichlorobenzene with an alkali metal lower alkoxide with heating at about 100.degree.-200.degree. C. for from about 1/2-24 hours in an inert organic solvent selected from the group consisting of dimethylformamide, dimethyl acetamide and dimethylsulfoxide and additionally in the presence of an alkanol selected from the group consisting of methanol and ethanol and said alkanol is present in the reaction mixture in a quantity sufficient to solvate the metal lower alkoxide reagent.
In the method of reacting 1,2,3-trichlorobenzene with sodium or potassium methoxide in dimethylacetamide, dimethylformamide or dimethylsulfoxide as solvent at temperatures of from 100.degree.-200.degree. until the reaction is complete, the improvement comprising adding to the reaction mixture a quantity of methanol sufficient to solvate said methoxide throughout the reaction.
Dependencies are inferred from the claim text.