1,2,2A,3,4,5 Hexahydrobenz[c,d]indol-1-yl-2-guanidines
AssigneeSandoz Ltd.
InventorsGerhard Bormann, Franz Troxler
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AssigneeSandoz Ltd.
InventorsGerhard Bormann, Franz Troxler
Estimating the term…
The present invention concerns novel compounds of formula I, ##STR1## wherein R.sub.1 is hydroxy, or ##STR2## wherein N IS AN INTEGER FROM 1 TO 5, AND R.sub.3 and R.sub.4 are independently alkyl of 1 to 4 carbon atoms, or R.sub.3 and R.sub.4 together form an alkylene chain of 2 or 3 carbon atoms, R.sub.2 is hydrogen, alkyl of 1 to 4 carbon atoms, phenylalkyl of 7 to 9 carbon atoms, or phenylalkyl of 7 to 9 carbon atoms mono- or disubstituted on the phenyl radical by halogen, alkyl of 1 to 4 carbon atoms or alkoxy of 1 to 4 carbon atoms, and Either X is hydrogen, and Y is methyl, Or X is methylthio or dialkylamino, wherein the alkyl chains are independently of 1 to 4 carbon atoms, and Y is hydrogen, Or X is chlorine or bromine, and Y is chlorine, Or, when R.sub.1 is the above acetal group, X also signifies hydrogen, chlorine, bromine or methyl, and Y signifies hydrogen, Useful as salidiuretics.
A compound of formula I, ##STR11## wherein R.sub.1 is hydroxy, or ##STR12## wherein n is an integer from 1 to 5, and
Dependencies are inferred from the claim text.