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US 4,057,557 AGranted
Certain 5-nitrothiazolylimidazolidine compounds
AssigneeSandoz Ltd.
InventorsGerd Ascher, Hellmuth Reinshagen
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Abstract
The invention provides novel 5-nitrothiazolylimidazoline derivatives, useful as chemotherapeutic agents.
Claims12
Compounds of formula I, ##STR13## in which R.sub.1 is hydrogen, lower alkyl or phenyl, R.sub.2 is hydrogen, lower alkyl or alkoxy, trifluoromethyl, the group --CH.dbd.CH--COOH or a group --N(R.sub.3)(R.sub.4), in which R.sub.3 and P.sub.4, which may be the same or different, each signifies hydrogen or lower alkyl, and
- X is oxygen, sulphur or imino, provided that when R.sub.2 is lower alkyl or --CH.dbd.CH--COOH, then X is oxygen,
- or a chemotherapeutically acceptable acid addition salt thereof.
Dependencies are inferred from the claim text.