Indolo[2,3-a]quinolizines
AssigneeRichter Gedeon Vegyeszeti Gyar Rt.
InventorsCsaba Szantay, Lajos Szabo, Gyorgy Kalaus, Egon Karpati, Laszlo Szporny
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AssigneeRichter Gedeon Vegyeszeti Gyar Rt.
InventorsCsaba Szantay, Lajos Szabo, Gyorgy Kalaus, Egon Karpati, Laszlo Szporny
Estimating the term…
New compounds of the general formula (I) ##STR1## wherein R stands for an alkyl group, have been prepared by reducing a compound of the general formula (II) ##STR2## wherein R stands for alkyl, B stands for H.sub.2 O or an X.sup.- anion derived from an acid, and if B is an X.sup.- anion, A represents hydrogen, whereas if B is H.sub.2 O, A represents an electron pair. If desired, the racemic compounds of the general formula (I) can be resolved to yield the corresponding optically active isomers. The free bases of the general formula (I) can be converted into their pharmaceutically acceptable salts, or the salts can be treated with an alkaline agent to yield the free bases. The compounds of the general formula (I) can be used in the therapy primarily as vasodilatating agents.
A compound of the formula (I), ##STR8## wherein R is an alkyl group having 1 to 6 carbon atoms, and a pharmaceutically acceptable salt thereof.
1.alpha.-Ethyl-1.beta.-(2-cyanoethyl)-1 ,2,3,4,6,7,12,12b.beta.-octahydro-indolo(2,3-a)quinolizine.
1.alpha.-n-Butyl-1.beta.-(2-cyanoethyl)-1,2,3,4,6,7,12,1 2b.beta.-octahydro-indolo(2,3-a)quinolizine.
1.alpha.-Ethyl-1.beta.-(2-cyanoethyl)-1,2 ,3,4,6,7,12,12b.beta.-octahydro-indolo(2,3-a)quinolizinium perchlorate.
1.alpha.-n-Butyl-1.beta.-(2-cyanoethyl)-1,2,3,4,6,7,12,12b.beta.-oct ahydro-indolo(2,3-a)quinolizinium perchlorate.
Dependencies are inferred from the claim text.