.alpha.-Alkylsulfobenzyl penicillins
AssigneeTakeda Chemical Industries, Ltd.
InventorsKeiichi Sugimoto, Koji Nishijima, Hiroshi Akimoto, Tadashi Hanaoka, Nobuharu Kakeya
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Abstract
Novel penicillins of the formula ##STR1## wherein R is a branched chain alkyl group of from 3 to 14 carbon atoms, and their pharmaceutically acceptable salts, are easily absorbed in the blood and tissues through oral administration and show excellent antimicrobial activity against Gram-positive and Gram-negative bacteria, particularly against microorganisms of the genus Pseudomonas, such as Pseudomonas aeruginosa.
Claims7
A penicillin compound selected from the group consisting of a compound of the formula ##STR77## wherein R is isopropyl, ##STR78## and a pharmaceutically acceptable salt thereof.
A penicillin compound selected from the group consisting of a compound of the formula ##STR82## wherein R is ##STR83## and a pharmaceutically acceptable salt thereof.
A compound of the formula ##STR84## wherein R is isopropyl.
Dependencies are inferred from the claim text.