Back to results
US 4,056,672 AGranted
Polymer prepared by cyanhydrin method
AssigneeAstra Lakemedel Aktiebolag
InventorsAlf-Goran Dahlberg, Karl Gustav Hogberg, Sven Lindvall, Thore Oskar Verner Rydh
Life of this patent
Estimating the term…
Abstract
The present invention relates to a process for preparing a polymer which is suitable for being administered parenterally from a saccharide, a polyhydric alcohol and a polymerization agent and to the polymer prepared therefrom. The invention relates also to an iron preparation suitable for parenteral -- intramuscular and intravenous -- injection, to a process for the preparation of the iron preparation, and to the use of the injectable iron preparations in human and veterinary medicine.
Claims26
A process for preparing a polymer which is suitable for being administered parenterally which comprises:
- A. reacting in an aqueous solution at a temperature between about 20.degree. C and the boiling point of the reaction mixture
- 1. about 0.1 to 1.0 moles of a saccharide (per mole of component (3) below) which is selected from the group consisting of
- a. sucrose,
- b. trehalose, and
- c. raffinose;
- 2. about 0.05 to 5 moles of a polymerization agent (per mole of component (3) below) of the formula ##STR13## wherein n is an integer selected from the group consisting of 0, 1, 2, 3 and 4;
- X is selected from the group consisting of Cl, Br and I;
- R.sup.1 is selected from the group consisting of OH, Cl, Br and I;
- and R.sup.2 is selected from the group consisting of H and CH.sub.2 X with the proviso that R.sup.2 is CH.sub.2 X only when R.sup.1 is OH, wherein X has the meaning specified above;
- the epoxides or the diepoxides derivable therefrom;
- and
- 3. a hexitol selected from the group consisting of sorbitol, hydroxypropyl sorbitol, mannitol, talitol, iditol, galactitol, and allitol to form a first intermediate of the formula ##STR14## B. reacting said first intermediate product with a cyanide selected from the group consisting of KCN, NaCN, Ca(CN).sub.2, HCN, and NH.sub.4 CN in an amount at least equimolar with the amount of carbonyl groups on the first intermediate product to form a second intermediate product of the formula ##STR15## C. acidifying said second intermediate product to form a third intermediate product of the formula ##STR16## D. hydrolyzing said third intermediate product to form a water swellable polymer of the formula ##STR17##
9 more elements
A polymer suitable for being administered parenterally which has been prepared by
- A. reacting in an aqueous solution at a temperature between about 20.degree. C and the boiling point of the reaction mixture
- 1. about 0.1 to 1.0 moles of a saccharide (per mole of component (3) below) which is selected from the group consisting of
- a. sucrose,
- b. trehalose, and
- c. raffinose;
- 2. about 0.05 to 5 moles of a polymerization agent (per mole of component (3) below) of the formula ##STR18## wherein n is an integer selected from the group consisting of 0, 1, 2, 3 and 4;
- X is selected from the group consisting of Cl, Br and I;
- R.sup.1 is selected from the group consisting of OH, Cl, Br and I;
- and R.sup.2 is selected from the group consisting of H and CH.sub.2 X with the proviso that R.sup.2 is CH.sub.2 X only when R.sup.1 is OH, wherein X has the meaning specified above;
- the epoxides or the diepoxides derivable therefrom;
- and
- 3.
9 more elements
A process for preparing a composition for treatment of iron deficiency by parenteral administration which comprises
- A. reacting in an aqueous solution at a temperature between about 20.degree. C and the boiling point of the reaction mixture
- 1. about 0.1 to 1.0 moles of a saccharide (per mole of component (3) below) which is selected from the group consisting of
- a. sucrose,
- b. trehalose, and
- c. raffinose;
- 2. about 0.05 to 5 moles of a polymerization agent (per mole of component (3) below) of the formula ##STR24## wherein n is an integer selected from the group consisting of 0, 1, 2, 3 and 4;
- X is selected from the group consisting of Cl, Br and I;
- R.sup.1 is selected from the group consisting of OH, Cl, Br and I;
- and R.sup.2 is selected from the group consisting of H and CH.sub.2 X with the proviso that R.sup.2 is CH.sub.2 X only when R.sup.1 is OH, wherein X has the meaning specified above;
- the epoxides or the diepoxides derivable therefrom;
- and
- 3. a hexitol selected from the group consisting of sorbitol, hydroxypropyl sorbitol, mannitol, talitol, iditol, galactitol, and allitol to form a first intermediate of the formula ##STR25## B. reacting said first intermediate product with a cyanide selected from the group consisting of KCN, NaCN, Ca(CN).sub.2, HCN, and NH.sub.4 CN in an amount at least equimolar with the amount of carbonyl groups on the first intermediate product to form a second intermediate product of the formula ##STR26## C. acidifying said second intermediate product to form a third intermediate product of the formula ##STR27## C. hydrolyzing said third intermediate product to form a water swellable polymer of the formula ##STR28## E. reacting said water swellable polymer with a ferric compound in solution under alkaline conditions to form a polymer complex of ferric iron.
9 more elements
Dependencies are inferred from the claim text.