D-homo-20-ketopregnanes and method for inducing anesthesia or narcosis
AssigneeSchering Corporation
InventorsUlrich Kerb, Rudolf Wiechert, Helmut Wachtel, Otto Engelfried, Klaus Kieslich
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Abstract
D-homo-20-ketopregnanes of the formula ##STR1## wherein R.sub.1 is hydrogen, fluorine, chlorine, bromine, alkyl, alkoxy, or azido; R.sub.2 is oxygen, ##STR2## and R.sub.7 is hydrogen, lower alkyl, or acyl of up to 5 carbon atoms; R.sub.3 is hydrogen or methyl R.sub.4 is oxygen, two hydrogens, ##STR3## R.sub.5 is hydrogen, hydroxy, alkoxy, azido, mercapto, thiocyano, cyano, dialkylamino, morpholino, thiomorpholino, or piperazino; R.sub.6 is methyl or ethyl; The hydrogen atom in the 5-position is of the .alpha.- or .beta.-configuration; And acid addition salts thereof, possess narcotic-anesthetic activity.
Claims37
A D-homo-20-ketopregnane of the formula ##STR14## wherein R.sub.1 is hydrogen, fluorine, chlorine, bromine, alkyl of 1-15 carbon atoms, alkoxy of 1-15 carbon atoms, or azido;
- R.sub.2 is oxygen ##STR15## and R.sub.7 is hydrogen, alkyl of 1-8 carbon atoms or alkanoyl of up to 5 carbon atoms;
- R.sub.3 is hydrogen or methyl;
- R.sub.4 is oxygen, two hydrogens, ##STR16## R.sub.5 is hydrogen, hydroxy, alkoxy of 1-15 carbon atoms or mercapto, R.sub.6 is methyl or ethyl;
- the hydrogen atom in the 5-position is in the .alpha.-or .beta.-configuration;
- and
- pharmaceutically acceptable acid addition salts thereof.
Dependencies are inferred from the claim text.