2-Hydroxymethyl-2'-aminomethyl-diphenylsulfides and method of use
AssigneeBurroughs Wellcome Co.
InventorsNariman Bomanshaw Mehta, Lawrence Edward Brieaddy
Life of this patent
Estimating the term…
Abstract
Compounds, pharmaceutical preparations containing same, and method of treating depression in mammals, the compounds being of the formula I ##STR1## or an acid addition salt thereof, particularly a pharmacologically or pharmaceutically acceptable salt thereof, where R and R.sup.1 are the same or different and are each hydrogen or lower alkyl, or R and R.sup.1 taken together are (CH.sub.2).sub.X where X is 4 or 5, or NRR.sup.1 is ##STR2## where Y is 3 or 4 and R.sup.3 is hydrogen or lower alkyl, or NRR.sup.1 is ##STR3## where R.sup.2 is hydrogen or lower alkyl, in the above lower alkyl has 1 to 4 carbons and may be straight or branched and n and m are the same or different and are 1, 2, or 3.
Claims61
A compound of the formula ##STR37## or an acid addition salt thereof where R and R.sup.1 are the same or different and are each hydrogen or lower alkyl, in the above lower alkyl has 1 to 4 carbon atoms and n and m are each 1.
2-Hydroxymethyl-2'-aminomethyiphenylsulfide.
2-hydroxymethyl-2'-dimethylaminomethyldiphenylsulfide.
2-Hydroxymethyl-2'-methylamino methyldiphenylsulfide.
A pharmaceutical composition comprising an effective antidepressant amount of the compound of the formula ##STR38## or a pharmaceutically acceptable acid addition salt thereof where R and R.sup.1 are the same or different and are each hydrogen or lower alkyl in the above lower alkyl has 1 to 4 carbon atoms and n and m are are each 1 and a pharmaceutically acceptable carrier therefore.
The method of treating depression in a mammal which comprises administering to a depressed mammal an effective antidepressant amount of a compound of the formula ##STR39## or a pharmaceutically acid addition salt thereof where R and R.sup.1 are the same or different and are each hydrogen or lower alkyl, in the above lower alkyl has 1 to 4 carbon atoms and n and m are each 1.
A pharmaceutically acceptable salt of 2-hydroxymethyl-2'-aminomethyldiphenylsulfide.
A pharmaceutically acceptable salt of 2-hydroxymethyl-2'-dimethylamino-methyl-diphenylsulfide.
A pharmaceutically acceptable salt of 2-hydroxymethyl-2'-methylaminomethyldiphenylsulfide.
Dependencies are inferred from the claim text.