Method of treating dermal inflammation

A method of treating inflammation in the dermal layers of mammals which comprises topically administering to the inflamed area of a patient an effective amount of a pyrrole of the formula ##STR3## wherein R is alkyl of from 1 to 6 carbon atoms, thienyl, phenyl, diphenyl or phenyl substituted by halogen, trifluoromethyl, alkyl of from 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, nitro, cyano or hydroxy;

• R.sup.1 is carboxy, alkoxycarbonyl of from 2 to 7 carbon atoms, carbamoyl, N-alkylcarbamoyl of from 2 to 7 carbon atoms, N,N-dialkylcarbamoyl of from 3 to 7 carbon atoms, hydroxycarbamoyl or dialkylphosphinylalkoxycarbonyl of from 4 to 10 carbon atoms;
• R.sup.2 is hydrogen, hydroxyl, mercapto, halogen, trifluoromethyl, alkoxy of from 1 to 6 carbon atoms, alkanoyloxy of from 1 to 6 carbon atoms, amino, alkanoylamino of from 1 to 6 carbon atoms, dialkylthiocarbamoyloxy of from 3 to 7 carbon atoms or dialkylcarbamoylthio of 3 to 7 carbon atoms;
• R.sup.3 is hydrogen, alkanoyl of from 1 to 6 carbon atoms or phenyl;
• X is alkylene of from 3 to 5 carbon atoms, alkylene of from 3 to 5 carbon atoms substituted by alkyl or alkoxy of from 1 to 6 carbon atoms, divinylene, divinylene substituted by alkyl of from 1 to 6 carbon atoms or ##STR4## wherein D is hydrogen, alkoxy of from 1 to 6 carbon atoms or halogen;
• and n is the integer 1 or 2.